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1

Myotoxicity of statins: Mechanism of action

du Souich, Patrick, Roederer, Ghislaine, Dufour, Robert

Journal:

Pharmacology & Therapeutics

Year:

2017

Language:

english

File:

PDF, 988 KB

english, 2017

2

Signal transduction pathways implicated in the decrease in CYP1A1, 1A2 and 3A6 activity produced by serum from rabbits and humans with an inflammatory reaction

Mihaela Levitchi, Caroline Fradette, Anne-Marie Bleau, Dorothée Michaud, Oksana Kourylko, Mathieu Arcand, Patrick du Souich

Journal:

Biochemical Pharmacology

Year:

2004

Language:

english

File:

PDF, 314 KB

english, 2004

3

Immunomodulatory and anti-inflammatory effects of chondroitin sulphate

Patrick Du Souich, Antonio G. García, Josep Vergés, Eulàlia Montell

Journal:

Journal of Cellular and Molecular Medicine

Year:

2009

Language:

english

File:

PDF, 7.69 MB

english, 2009

4

Pharmacokinetic and pharmacodynamic effects of midodrine on blood pressure, the autonomic nervous system, and plasma natriuretic peptides: a prospective, randomized, single-blind, two-period, crossover, placebo-controlled study

Maxime Lamarre-Cliche, Patrick du Souich, Jacques de Champlain, Pierre Larochelle

Journal:

Clinical Therapeutics

Year:

2008

Language:

english

File:

PDF, 685 KB

english, 2008

5

Sulfamethazine absorption and disposition: Effect of surgical procedures for gastroduodenal ulcers

Rosario Calvo, Sebastian Sarabia, Raimundo Carlos, Patrick Du Souich

Journal:

Biopharmaceutics & Drug Disposition

Year:

1987

Language:

english

File:

PDF, 471 KB

english, 1987

6

Pharmacodynamics as a tool to assess the bioequivalence of nonystemically available drugs: Size of the sample required

Patrick Du Souich, Jean-Guy Besner, Gilles Caille

Journal:

Biopharmaceutics & Drug Disposition

Year:

1992

Language:

english

File:

PDF, 502 KB

english, 1992

7

Effect of omeprazole on oral and intravenous RS-methadone pharmacokinetics and pharmacodynamics in the rat

M. Angeles Carlos, Patrick Du Souich, Raimundo Carlos, Elena Suarez, John C. Lukas, Rosario Calvo

Journal:

Journal of Pharmaceutical Sciences

Year:

2002

Language:

english

File:

PDF, 150 KB

english, 2002

8

Cytochrome P-450 content and activity after cold storage of rat hepatocytes in university of wisconsin and sodium-lactobionate-sucrose solutions

Halima Serrar, Ayman El-Kadi, Patrick Du Souich, Pierre Haddad

Journal:

Liver Transplantation

Year:

1999

Language:

english

File:

PDF, 137 KB

english, 1999

9

Analysis of albuterol in human plasma based on immunoaffinity chromatograhic clean-up combined with high-performance liquid chromatography with fluorimetric detection

Huy Ong, Albert Adam, Sylvie Perreault, Sylvie Marleau, Monique Bellemare, Patrick Du Souich, Normand Beaulieu

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1989

Language:

english

File:

PDF, 587 KB

english, 1989

10

Simple and rapid radioimmunoassay for the routine determination of vasopressin in plasma

Patrice Larose, Huy Ong, Patrick Du Souich

Journal:

Clinical Biochemistry

Year:

1985

Language:

english

File:

PDF, 514 KB

english, 1985

11

Acute moderate hypoxia reduces ethanol elimination in the conscious rabbit

Joanne Gavalakis, Patrick du Souich, Mahmoud Sharkawi

Journal:

Year:

1999

Language:

english

File:

PDF, 109 KB

english, 1999

12

Furosemide dynamics in conscious rabbits: Modulation by arginine vasopressin

Roberto Babini, Patrick Souich

Journal:

Cardiovascular Drugs and Therapy

Year:

1995

Language:

english

File:

PDF, 592 KB

english, 1995

13

Furosemide dynamics in conscious rabbits: Modulation by angiotensin II

Walid Homsy, Sylvie Marleau, Patrick Souich

Journal:

Cardiovascular Drugs and Therapy

Year:

1995

Language:

english

File:

PDF, 743 KB

english, 1995

14

Chondroitin Sulfate Inhibits the Nuclear Translocation of Nuclear Factor-κB in Interleukin-1β-Stimulated Chondrocytes

Claudia Jomphe, Mélanie Gabriac, Taben M. Hale, Lucie Héroux, Louis-Éric Trudeau, Denis Deblois, Eulalia Montell, Josep Vergés, Patrick Du Souich

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2008

Language:

english

File:

PDF, 212 KB

english, 2008

15

Tocainide kinetics and metabolism: Effects of phenobarbital and substrates for glucuronyl transferase

Elvin, Alfred T, Lalka, David, Stoeckel, Klaus, Souich, Patrick Du, Axelson, James E, Golden, Lawrence H, McLean, Allan J

Journal:

Clinical Pharmacology & Therapeutics

Year:

1980

Language:

english

File:

PDF, 481 KB

english, 1980

16

Effect of aminoglycosides on the disposition of thyroid hormones and thyroglobulin

Souich, Patrick Du, Pison, Cesar, Pedneault, Louise, Larochelle, Pierre, Morisset, Richard, Vega, Carlos, Phaneuf, Denis, Poisson, Michel

Journal:

Clinical Pharmacology & Therapeutics

Year:

1985

Language:

english

File:

PDF, 489 KB

english, 1985

17

Down-regulation of the hepatic cytochrome P450 by an acute inflammatory reaction: implication of mediators in human and animal serum and in the liver

Ayman O S El-Kadi, Hélène Maurice, Huy Ong, Patrick du Souich

Journal:

British Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 314 KB

english, 1997

18

21-Aminosteroids prevent the down-regulation of hepatic cytochrome P450 induced by hypoxia and inflammation in conscious rabbits

Ahmed Galal, Patrick Du Souich

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 163 KB

english, 1999

19

Cytochrome P450 inactivation by serum from humans with a viral infection and serum from rabbits with a turpentine-induced inflammation: the role of cytokines

Anne-Marie Bleau, Mihaela C Levitchi, Hélène Maurice, Patrick Du Souich

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 193 KB

english, 2000

20

Hypoxia-induced down-regulation of CYP1A1/1A2 and up-regulation of CYP3A6 involves serum mediators

Caroline Fradette, Anne-Marie Bleau, Vincent Pichette, Nathalie Chauret, Patrick Du Souich

Journal:

British Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 372 KB

english, 2002

21

Hypoxia-inducible factor-1 and activator protein-1 modulate the upregulation of CYP3A6 induced by hypoxia

Caroline Fradette, Patrick du Souich

Journal:

British Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 361 KB

english, 2003

22

5-Hydroxytryptamine is biotransformed by CYP2C9, 2C19 and 2B6 to hydroxylamine, which is converted into nitric oxide

Caroline Fradette, Nobuharu Yamaguchi, Patrick Du Souich

Journal:

British Journal of Pharmacology

Year:

2004

Language:

english

File:

PDF, 249 KB

english, 2004

23

Hepatic Extraction of Hexarelin, a New Peptidic GH Secretagogue, in the Isolated Perfused Rat Liver

Marie Roumi, Sylvie Marleau, Muny Boghen, Magnus Nilsson, Patrick Du Souich, Huy Ong

Journal:

Pharmaceutical Research

Year:

1997

File:

PDF, 488 KB

1997

24

First-Pass Metabolism of Diltiazem in Anesthetized Rabbits: Role of Extrahepatic Organs

Marc Lefebvre, Walid Homsy, Gilles Caillé, Patrick du Souich

Journal:

Pharmaceutical Research

Year:

1996

File:

PDF, 912 KB

1996

25

The Site of Absorption in the Small Intestine Determines Diltiazem Bioavailability in the Rabbit

Walid Homsy, Gilles Caillé, Patrick du Souich

Journal:

Pharmaceutical Research

Year:

1995

File:

PDF, 1.02 MB

1995

26

Metabolism of Diltiazem in Hepatic and Extrahepatic Tissues of Rabbits:InVitroStudies

Walid Homsy, Marc Lefebvre, Gilles Caillé, Patrick du Souich

Journal:

Pharmaceutical Research

Year:

1995

File:

PDF, 1.05 MB

1995

27

Salbutamol disposition and dynamics in conscious rabbits: Influence of the route of administration and of the dose

Sylvie Perreault, Huy Ong, Patrick du Souich

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1992

Language:

english

File:

PDF, 896 KB

english, 1992

28

Lack of presystemic metabolism of nifedipine in the rabbit

Patrick du Souich, Lucie Héroux, Hélène Maurice, Michelle Dépôt, Gilles Caillé

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1995

Language:

english

File:

PDF, 772 KB

english, 1995

29

Pharmacokinetic analysis of absorption, distribution and disappearance of ingested water labeled with D2O in humans

Péronnet, François, Mignault, Diane, du Souich, Patrick, Vergne, Sébastien, Le Bellego, Laurent, Jimenez, Liliana, Rabasa-Lhoret, Rémi

Journal:

European Journal of Applied Physiology

Year:

2012

Language:

english

File:

PDF, 331 KB

english, 2012

30

Correlation between acetone-potentiated CCl4-induced liver injury and blood concentrations after inhalation or oral administration

Michel Charbonneau, Jules Brodeur, Patrick du Souich, Gabriel L. Plaa

Journal:

Toxicology and Applied Pharmacology

Year:

1986

Language:

english

File:

PDF, 714 KB

english, 1986

31

The influence of severity of bile flow reduction, cycloheximide, and methyl isobutyl ketone pretreatment on the kinetics of taurolithocholic acid disposition in the rat

Lena Dahlström-King, Patrick du Souich, Johanne Couture, Gabriel L. Plaa

Journal:

Toxicology and Applied Pharmacology

Year:

1990

Language:

english

File:

PDF, 785 KB

english, 1990

32

The 21-aminosteroid U74389G prevents the down-regulation and decrease in activity of CYP1A1, 1A2 and 3A6 induced by an inflammatory reaction

Mehrzad Taherzadeh, Caroline Fradette, Anne-Marie Bleau, Claudia Jomphe, Louis-Éric Trudeau, Patrick du Souich

Journal:

Biochemical Pharmacology

Year:

2006

Language:

english

File:

PDF, 1.04 MB

english, 2006

33

Effect of chondroitin sulfate on turpentine-induced down-regulation of CYP1A2 and CYP3A6

Mirela-Onita Iovu, Lucie Héroux, Josep Vergés, Eulália Montell, Jacques Paiement, Patrick du Souich

Journal:

Carbohydrate Research

Year:

2012

Language:

english

File:

PDF, 452 KB

english, 2012

34

An Open-Label, Multi-Dose Efficacy and Safety Study of Intramuscular Tetrodotoxin in Patients with Severe Cancer-Related Pain

Neil A. Hagen, Kim M. Fisher, Bernard Lapointe, Patrick du Souich, Srini Chary, Dwight Moulin, Ed Sellers, Anh Ho Ngoc

Journal:

Journal of Pain and Symptom Management

Year:

2007

Language:

english

File:

PDF, 323 KB

english, 2007

35

Tetrodotoxin for Moderate to Severe Cancer Pain: A Randomized, Double Blind, Parallel Design Multicenter Study

Neil A. Hagen, Patrick du Souich, Bernard Lapointe, May Ong-Lam, Benoit Dubuc, David Walde, Robin Love, Anh Ho Ngoc

Journal:

Journal of Pain and Symptom Management

Year:

2008

Language:

english

File:

PDF, 244 KB

english, 2008

36

Temporal effects of left versus right middle cerebral artery occlusion on spleen lymphocyte subsets and mitogenic response in Wistar rats

Alain Gendron, Jeanne Teitelbaum, Chantal Cossette, Stephen Nuara, Marc Dumont, David Geadah, Patrick du Souich, Edouard Kouassi

Journal:

Year:

2002

Language:

english

File:

PDF, 403 KB

english, 2002

37

Interleukin-1β, interleukin-6, tumour necrosis factor-α and interferon-γ released by a viral infection and an aseptic inflammation reduce CYP1A1, 1A2 and 3A6 expression in rabbit hepatocytes

Anne-Marie Bleau, Patrick Maurel, Vincent Pichette, François Leblond, Patrick du Souich

Journal:

European Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 453 KB

english, 2003

38

Extrahepatic metabolism of frusemide in anaesthetized rabbits

José Vergés, Lucie Héroux, Hélène Maurice, Patrick du Souich

Journal:

British Journal of Pharmacology

Year:

1995

Language:

english

File:

PDF, 1.18 MB

english, 1995

39

The influence of moderate hypoalbuminaemia on the renal metabolism and dynamics of furosemide in the rabbit

Vincent Pichette, David Geadah, Patrick du Souich

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.23 MB

english, 1996

40

Effects of concurrent sucralfate administration on pharmacokinetics of naproxen

Gilles Caille, Patrick du Souich, Pierre Gervais, Jean Guy Besner, Manon Vezina

Journal:

The American Journal of Medicine

Year:

1987

Language:

english

File:

PDF, 676 KB

english, 1987

41

Effects of food and sucralfate on the pharmacokinetics of naproxen and ketoprofen in humans

Gilles Caillé, Patrick du Souich, Jean Guy Besner, Pierre Gervais, Manon Vézina

Journal:

The American Journal of Medicine

Year:

1989

Language:

english

File:

PDF, 825 KB

english, 1989

42

Effects of acetone and methyl n-butyl ketone on hepatic mixed-function oxidase

Adriane B. Kobusch, Gabriel L. Plaa, Patrick Du Souich

Journal:

Biochemical Pharmacology

Year:

1989

Language:

english

File:

PDF, 802 KB

english, 1989

43

Recombinant bovine growth hormone-induced reduction of atrial natriuretic peptide is associated with improved left ventricular contractility and reverse remodeling in cardiomyopathic UM-X7.1 hamsters with congestive heart failure

Mukandila Mulumba, Catia Céméus, Louis Dumont, Patrick du Souich, Huy Ong, Sylvie Marleau

Journal:

Growth Hormone & IGF Research

Year:

2007

Language:

english

File:

PDF, 209 KB

english, 2007

44

L-NAME prevents in vivo the inactivation but not the down-regulation of hepatic cytochrome P450 caused by an acute inflammatory reaction

Maxime M. Barakat, Ayman O.S. El-Kadi, Patrick du Souich

Journal:

Year:

2001

Language:

english

File:

PDF, 306 KB

english, 2001

45

Depression of the hepatic cytochrome P450 by an acute inflammatory reaction: Characterization of the nature of mediators in human and rabbit serum, and in the liver

Ayman O.S. El-Kadi, Patrick Du Souich

Journal:

Year:

1998

Language:

english

File:

PDF, 818 KB

english, 1998

46

Permeability of the peptidic GH secretagogues hexarelin and EP 51389, across rat jejunum

Marie Roumi, Elizabeth Kwong, Romano Deghenghi, Vittorio Locatelli, Sylvie Marleau, Patrick Du Souich, Richard Béliveau, Huy Ong

Journal:

Year:

2001

Language:

english

File:

PDF, 355 KB

english, 2001

47

Effect of lignocaine on arginine-vasopressin plasma levels: baseline or induced by frusemide

Louise Gariépy, Patrice Larose, Benoit Bailey, Patrick du Souich

Journal:

British Journal of Pharmacology

Year:

1992

Language:

english

File:

PDF, 1.20 MB

english, 1992

48

The effect and clinical consequences of hypoxia on cytochrome P450, membrane carrier proteins activity and expression

du Souich, Patrick, Fradette, Caroline

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Year:

2011

Language:

english

File:

PDF, 679 KB

english, 2011

49

Effect of salbutamol on gastroesophageal reflux in healthy volunteers and patients with asthma

Michoud, Marie Claire, Leduc, Tam, Proulx, France, Perreault, Sylvie, Souich, Patrick Du, Duranceau, André, Amyot, Robert

Journal:

Journal of Allergy and Clinical Immunology

Year:

1991

Language:

english

File:

PDF, 618 KB

english, 1991

50

What is the clinical meaning of the acetylator phenotype?

Patrick du Souich, Chantal Lambert

Journal:

Trends in Pharmacological Sciences

Year:

1981

Language:

english

File:

PDF, 351 KB

english, 1981

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